Flow Cytometry Analyzer Supplies
AdipoGen IL-27 msFc-KIH h rec
Recombinant protein. IL-27A/p28 aa 29-234 mouseFc Knobs and IL-27B/EBI3 aa 19-228 mouseFc Holes form the IL-27 mouseFc-KIH human using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Activates STAT3 phosphorylation in mouse and human cells. Source CHO cells. Lyophilized. Contains PBS Interleukin-12 IL-12 family members are heterodimer glycoproteins, composed of two covalently linked subunits, alpha and beta chains. The alpha-subunit consists of IL-23p19, IL-27p28, and IL-12p35, and the beta-subunit includes IL-12p40 and Epstein-Barr virus-induced gene Ebi3. IL-12 members bind to cognate heterodimeric receptor chains expressed on T cells. This family includes IL-12, IL-23, IL-27 and IL-35 and IL-39. IL-12 and IL-23 are predominantly proinflammatory cytokines that contribute key roles in the development of Th1 and Th17 cells, respectively.
AdipoGen IL-2 hmonomericFc-KIH h
Recombinant Protein. Human IL-2 aa 21-153 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.IL-2 promotes T cell proliferation and particularly naive T cells.
AdipoGen IL-37 hmonomericFc-KIHh
Recombinant Protein. Human IL-37 aa 46-218 Delta5CysS-S and Y85A see reference A. Bujotzek, et al. 2022 is fused at the C-terminus to a Fc human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-37 IL-1F7 IL-1H4 is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells PBMCs and dendritic cells. IL-37 is a soluble and secreted cytokine of 218 residues that shares the beta-trefoil fold common to IL-1 family cytokines. But IL-37 is an atypical member of the IL-1 family of cytokines as it functions to inhibit many of the major pathways of innate and adaptive immunity and inflammation. It binds to the interleukin-18 receptor IL-18R and its co-receptor SIGIRR.
AdipoGen Fc LALA-PG-KIHIrisin mono
Recombinant protein. Fc LALA-PG KnobsIrisin human, aa 32-143 /mouse, aa 29-140 and Fc LALA-PG Holes form the Fc LALA-PG-KIH humanIrisin monomeric rec. using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin. Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
AdipoGen IL-2 Superk MonomFc-KIHh
Recombinant Protein. Human IL-2 aa 21-153 mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
AdipoGen IL-12 msFc-KIH h rec
Recombinant protein. IL-12A/p35 aa 23-215 mouseFc Knobs and IL-12B/p40 aa 23-335 mouseFc Holes form the IL-12 mouseFc-KIH human using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source CHO cells. Lyophilized. Contains PBS Interleukin-12 IL-12 family members are heterodimer glycoproteins, composed of two covalently linked subunits, alpha and beta chains. The alpha-subunit consists of IL-23p19, IL-27p28 and IL-12p35, and the beta-subunit includes IL-12p40 and Epstein-Barr virus-induced gene Ebi3. IL-12 members bind to cognate heterodimeric receptor chains expressed on T cells. This family includes IL-12, IL-23, IL-27, IL-35 and IL-39. IL-12 and IL-23 are predominantly proinflammatory cytokines that contribute key roles in the development of Th1 and Th17 cells, respectively. IL-27 has both pro- and anti-inflammatory properties and is a potent T cell immunomodulator.
AdipoGen IL-2 hSwitch-2monome-KIH
Recombinant protein. The extracellular domain of human IL-2 aa 21-153 mutant pH-resistant Switch-2 containing mutations T37H, R38L, T41S, F42Y, and K43G is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta.
AdipoGen IL-2 hmonomericFc-KIH h
Recombinant Protein. Human IL-2 aa 21-153 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.IL-2 promotes T cell proliferation and particularly naive T cells.
AdipoGen IL-38 aa20-152hmonom-KIH
Recombinant Protein. Human IL-38 aa 20-152 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-38 IL-1F10 belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells.
AdipoGen IL-2 Superkine FcH9T
Recombinant Protein. The extracellular domain of human IL-2 aa 21-153 mutant H9T containing the mutations of H9 L80F / R81D / L85V / I 86V / I92F and the new mutation Q126T is fused at the C-terminus to the Fc portion of human IgG2. Lyophilized. Contains PBS. Binds to human and mouse IL-2R. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
STEMCELL Technologies Fixation Buffer, 100 mL
Ready-to-use buffer to preserve cells prior to intracellular staining or flow cytometry
Cell Signaling Technology Cell Stimulation Cocktail (without Protein Transport Inhibitors) (500X) 100 µl
Cell Stimulation Cocktail (without Protein Transport Inhibitors) (500X) 100 µl
Cytek Biosciences Inc Cell Stimulation Cocktail (w/o protein transport inhibitors) (500X)
Cell Stimulation Cocktail (w/o protein transport inhibitors) (500X) ..... Cat. No. TNB-4970-UL400 ..... Size 400 µL